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SOLUNUM SİSTEMİ

Karşılaşılan maddeye karşı antikor saptanır

Tip III ve IV immün yanıt rol alır.

fibrozis ve mononükleer hücrelerin oluşturduğu interstisyel infiltratlar

 

 

 

 

 

 

 

Hypersensitivity Pneumonitis (HP)
Disease Antigen Source of Antigen
Bagassosis Thermophilic actinomycetes “Moldy” bagasse (sugar cane)
Bird fancier’s, breeder’s, or handler’s lung Parakeet, pigeon, chicken, turkey proteins Avian droppings or feathers
Cephalosporium HP Contaminated basement (sewage) Cephalosporium
Cheese washer’s lung Penicillium casei Moldy cheese
Chemical worker’s lungb Isocyanates Polyurethane foam, varnishes, lacquer
Coffee worker’s lung Coffee bean dust Coffee beans
Compost lung Aspergillus Compost
Detergent worker’s disease Bacillus subtilis enzymes (subtilisins) Detergent
Familial HP Bacillus subtilis Contaminated wood dust in walls
Farmer’s lungb Thermophilic actinomycetesa “Moldy” hay, grain, silage
Fish food lung Unknown Fish food
Fish meal worker’s lung Fish meal dust Fish meal
Furrier’s lung Animal fur dust Animal pelts
Hot tub lung Cladosporium spp., Mycobacterium avium complex Mold on ceiling; contaminated water
Humidifier or air-conditioner lung (ventilation pneumonitis) Aureobasidium pullulans, Candida albicans, Thermophilic actinomycetesa, mycobacterium spp., other microorganisms Contaminated water in humidification or forced-air air-conditioning systems
Japanese summer-type HP Trichosporon cutaneum , T. asahii, and T. mucoides House dust? Bird droppings
Laboratory worker’s HP Male rat urine Laboratory rat
Lycoperdonosis Lycoperdon puffballs Puffball spores
Malt worker’s lung Aspergillus fumigatus or A. clavatus Moldy barley
Maple bark disease Cryptostroma corticale Maple bark
Metalworking fluid lung Mycobacterium spp., Pseudomonas spp. Contaminated metalworking fluid
Miller’s lung Sitophilus granarius (wheat weevil) Infested wheat flour
Miscellaneous medication Amiodarone, bleomycin, efavirenz, gemcitabine, hydralazine, hydroxyurea, isoniazid, methotrexate, paclitaxel, penicillin, procarbazine, propranolol, riluzole, sirolimus, sulfasalazine Medication
Mushroom worker’s lung Thermophilic actinomycetes,a Hypsizigus marmoreus, Bunashimeji, and other exotic mushrooms Mushroom compost; mushrooms
Pituitary snuff taker’s lung Animal proteins Heterologous pituitary snuff
Potato riddler’s lung Thermophilic actinomycetes,a Aspergillus “Moldy” hay around potatoes
Sauna taker’s lung Aureobasidium spp., other Contaminated sauna water
Sausage worker’s lung Penicillium nalgiovense Dry sausage mold
Sequoiosis Aureobasidium, Graphium spp. Redwood sawdust
Streptomyces albus HP Streptomyces albus Contaminated fertilizer
Suberosis Penicillium glabrum and Chrysonilia sitophila Cork dust
Tap water lung Mycobacteria spp. Contaminated tap water
Thatched roof disease Sacchoromonospora viridis Dried grasses and leaves
Tobacco worker’s disease Aspergillus spp. Mold on tobacco
Winegrower’s lung Botrytis cinerea Mold on grapes
Wood trimmer’s disease Rhizopus spp., Mucor spp. Contaminated wood trimmings
Woodman’s disease Penicillium spp. Oak and maple trees
Woodworker’s lung Wood dust, Alternaria Oak, cedar, pine, and mahogany dusts

Çiftçi akciğeri

Termofilik aktinomyçetesler rol oynar.

Üzerine en sık sekonder bakteriyel pnömoni olarak Stafilokoklar biner

Klinik:

halsizlik

ateş

terleme

göğüste dolgunluk hissi

Wheezing olmadan öksürük

 akut atakta akciğer grafisinde infiltrasyonlar

restriktif tipte solunum bozukluğu içerir

Tanı:

Akciğer biopsisi

BAL

Çiftçi akciğeri

Tedavi:

Etkenden kaçınma

Akut atak sırasında kortikosteroidler

Çiftçi akciğerinde etkenle temasın kesilmesi ile tam iyileşmenin sağlanması karakteristiktir

 

GOODPASTURE SENDROMU

Akciğer ve böbreklerin progressif otoimmün hastalığıdır.

İntraalveolar hemoraji ve glomerulonefrite yol açar.

Tüm yaşlarda görülür.Erkeklerde daha sıktır

Ig G tipinde anti- glomeruler bazal membran antikorları

Antikorlar glomeruller alveoller ve kapillerin bazal membranında lineer birikim oluşturur.

Tip 2 hipersensitivite reaksiyonu

Akciğerlerde

diffüz kapiller sızıntı

İntraalveolar hemoraji (en sık intrapulmoner hemoraji nedenidir)

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